Hormonal

GLP-1RA users demonstrated significantly reduced pseudarthrosis rates at all time points: 6 months (8% vs. 12%; OR=0.702), 12 months (OR=0.730), and 24 months postoperatively (OR=0.788).

GLP-1RAs may be beneficial in reducing complications like pseudarthrosis in ACDF patients.

StrongSupportsmedium confidence

GLP-1RA users demonstrated significantly reduced pseudarthrosis rates at all time points: 6 months (8% vs. 12%; OR=0.702; 95%CI=0.555-0.888), 12 months (OR=0.730; 95%CI=0.582-0.915), and 24 months postoperatively (OR=0.788; 95% CI=0.634-0.979).

Norman Bank et al. · World Neurosurgery · 2025

Why this rating

Based on a retrospective cohort study design with a large sample size.

Source

The Effect of GLP-1 Receptor Agonists on Reoperation Following Anterior Cervical Discectomy and Fusion

Norman Bank et al. · World Neurosurgery · 2025

cohort · n=3184Cited 1×

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