Research
Molecular
The comparative bioavailability of semaglutide following oral administration (3 mg) relative to subcutaneous administration (0.25 mg) is 0.66%.
Practitioners should note the lower bioavailability of oral semaglutide compared to subcutaneous administration.
StrongSupportsmedium confidence
The comparative bioavailability (PO relative to SC) was 0.66 % at the doses administered.
Why this rating
The study involves a controlled evaluation of pharmacokinetics in healthy subjects.
Source
The pharmacokinetics and comparative bioavailabilty of oral and subcutaneous semaglutide in healthy volunteers
Mohammed Bouhajib et al. · Journal of Basic and Clinical Physiology and Pharmacology · 2025
DOI 10.1515/jbcpp-2025-0026
other · n=22Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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