Macro partitioning
In females with type 2 diabetes, the combination of low fat mass and low muscle mass is synergistically associated with higher glycated hemoglobin (A1C) levels compared to other body composition phenotypes.
If you are a woman with type 2 diabetes, do not assume that being thin means your blood sugar is well-managed. This research shows that having low body fat AND low muscle mass is a specific risk factor for higher blood sugar levels. To improve your A1C, focus on building muscle mass through resistance training, rather than just trying to lose weight or stay thin.
in females, low fat mass and low muscle mass were synergistically associated with higher A1C. This result suggests that low muscle mass has deleterious effects on A1C only when combined with low fat mass in females.
Why this rating
Large secondary analysis of the Look AHEAD trial (n=1,369) with rigorous statistical adjustment for covariates, though observational in nature regarding the baseline interaction.
Source
Sex-specific associations of fat mass and muscle mass with cardiovascular disease risk factors in adults with type 2 diabetes living with overweight and obesity: secondary analysis of the Look AHEAD trial
Tasuku Terada et al. · Cardiovascular Diabetology · 2022
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →