Macro partitioning
In males with type 2 diabetes, high fat mass is significantly associated with higher A1C, but muscle mass does not significantly influence A1C levels.
If you are a man with type 2 diabetes, your blood sugar levels are more closely linked to your body fat than your muscle mass. While building muscle is healthy, prioritizing fat loss through diet and exercise is likely to have a more direct impact on lowering your A1C levels.
In males, only high‑FMI was associated with higher A1C when compared to low‑FMI (57.1 ± 14.4 vs. 54.2 ± 12.0 mmol/mol, p = 0.008) at baseline.
Why this rating
Large secondary analysis of the Look AHEAD trial with statistical adjustment for covariates.
Source
Sex-specific associations of fat mass and muscle mass with cardiovascular disease risk factors in adults with type 2 diabetes living with overweight and obesity: secondary analysis of the Look AHEAD trial
Tasuku Terada et al. · Cardiovascular Diabetology · 2022
DOI 10.1186/s12933-022-01468-x
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