Research
Molecular
Defects in mitochondrial oxidative phosphorylation contribute to insulin resistance and β-cell apoptosis.
Addressing mitochondrial oxidative phosphorylation may improve insulin sensitivity.
StrongSupportsmedium confidence
It outlines how defects in mitochondrial oxidative phosphorylation, increased free radical production, and mitochondrial DNA damage contribute to insulin resistance, β-cell apoptosis, and systemic metabolic dysfunctions.
Why this rating
The review synthesizes multiple studies on this topic.
Source
Advancements in understanding the role and mechanisms of mitochondria in diabetes: A comprehensive review
Xia Ge et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2025
reviewCited 1×
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