Hormonal
Semaglutide (2.4 mg/weekly) significantly reduces the risk of major adverse cardiovascular events (MACE) in patients with overweight or obesity without diabetes, while also producing substantial weight loss and improving heart failure symptoms in those with preserved ejection fraction.
If you have heart disease or high risk for it, along with excess weight, semaglutide (Ozempic/Wegovy) is a highly effective treatment. It is taken as a once-weekly injection, starting at a low dose and increasing over 4 months to 2.4 mg. It significantly lowers your risk of heart attack and stroke, helps you lose about 9-13% of your body weight, and improves heart failure symptoms if you have them. Common side effects like nausea are usually temporary and manageable.
Treatment with semaglutide for approximately 33 months resulted in a mean body weight loss of 9.4% and a 20% reduction of the 3P-MACE composite risk (HR 0.80; 95% CI 0.72 to 0.90; p < 0.001)... The mean change in KCCQ-CSS at week 52... was 16.6 points in the semaglutide group... The other dual primary endpoint, the mean percentage change in body weight at week 52 was − 13.3% in the semaglutide group
Why this rating
Based on large-scale, randomized, placebo-controlled outcome trials (SELECT, STEP-HFpEF) with rigorous endpoints.
Source
CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes
Oliver Schnell et al. · Cardiovascular Diabetology · 2024
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