Research
Hormonal
Bempedoic acid (180 mg daily) reduces major adverse cardiovascular events (MACE) in high-risk patients who are unable or unwilling to take statins, primarily by lowering LDL cholesterol and reducing coronary revascularization needs.
If you have high cholesterol and a history of heart disease but cannot take statins due to side effects, bempedoic acid (180 mg daily) is an effective alternative. It lowers LDL cholesterol and significantly reduces your risk of heart attack, stroke, and the need for coronary procedures. It is taken once daily.
StrongSupportsVERY_HIGH confidence
Following a median 40.6 months trial follow-up, a primary endpoint MACE event was observed in 11.7%... of the patients in the bempedoic acid group and in 13.3%... of the patients of the placebo group, resulting in a significant 13% lower MACE incidence in the treatment group (hazard ratio (HR) 0.87; 95% confidence interval (CI) 0.79 to 0.96; p = 0.004)
Why this rating
Based on a large, randomized, placebo-controlled trial (CLEAR Outcomes).
Source
CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes
Oliver Schnell et al. · Cardiovascular Diabetology · 2024
DOI 10.1186/s12933-024-02180-8
narrative_reviewCited 24×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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