Research
Hormonal
GLP-1 receptor agonists (GLP-1RA) significantly reduce major adverse cardiovascular events (MACE) with a pooled hazard ratio of 0.86.
GLP-1RA can be recommended for reducing cardiovascular risks in patients with type 2 diabetes and obesity.
StrongSupportsmedium confidence
GLP-1RA significantly reduced MACE (pooled hazard ratio 0.86; 95% confidence interval 0.81-0.91).
Why this rating
Based on a meta-analysis of randomized controlled trials.
Source
Ambulatory blood pressure monitoring strengthens the cardiovascular signal of GLP-1RA: a meta-analysis of blood pressure and weight mediation
Nicolás Renna et al. · Journal of Hypertension · 2025
Meta-analysis
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →