Research
Hormonal
Tirzepatide significantly improved physical function compared with placebo, with a mean difference of 10.10 points in the IWQOL-Lite-CT physical function subscale.
Practitioners can consider tirzepatide as an effective treatment to enhance physical function in adults with overweight or obesity.
StrongSupportsmedium confidence
Tirzepatide significantly improved physical function compared with placebo, both in IWQOL‐Lite‐CT physical function (MD 10.10 points; 95% CI, 8.61–11.60; I 2 = 99.8%; p < 0.001).
Why this rating
Based on a systematic review and meta-analysis of randomized controlled trials.
Source
Tirzepatide on physical function in adults with overweight or obesity: A systematic review and meta‐analysis
P Schmidt et al. · Diabetes Obesity and Metabolism · 2026
DOI 10.1111/dom.70529
Meta-analysis
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide significantly improved physical function compared with placebo, with a mean difference of 2.26 points in the SF-36 physical function domain.Strong
- The overall certainty of evidence for the effects of tirzepatide on physical function was rated as moderate due to risk of bias and inconsistency across studies.Strong
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