Research
Hormonal
Tirzepatide significantly improved physical function compared with placebo, with a mean difference of 10.10 points in the IWQOL-Lite-CT physical function subscale.
Practitioners can consider tirzepatide as an effective treatment to enhance physical function in adults with overweight or obesity.
StrongSupportsmedium confidence
Tirzepatide significantly improved physical function compared with placebo, both in IWQOL‐Lite‐CT physical function (MD 10.10 points; 95% CI, 8.61–11.60; I 2 = 99.8%; p < 0.001).
Why this rating
Based on a systematic review and meta-analysis of randomized controlled trials.
Source
Tirzepatide on physical function in adults with overweight or obesity: A systematic review and meta‐analysis
P Schmidt et al. · Diabetes Obesity and Metabolism · 2026
Meta-analysis
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