Research
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The overall certainty of evidence for the effects of tirzepatide on physical function was rated as moderate due to risk of bias and inconsistency across studies.
Practitioners should be aware of the moderate certainty of evidence when considering tirzepatide for improving physical function.
StrongQualifiesmedium confidence
The overall certainty of evidence, rated by GRADE, was moderate due to risk of bias and inconsistency across studies.
Why this rating
Based on a systematic review and meta-analysis of randomized controlled trials.
Source
Tirzepatide on physical function in adults with overweight or obesity: A systematic review and meta‐analysis
P Schmidt et al. · Diabetes Obesity and Metabolism · 2026
DOI 10.1111/dom.70529
Meta-analysis
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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