Research
Metabolic adaptation
Adjustment for covariates differing between trial type and associated with BW reduction nullified the association between T2D status and weight loss (p = 0.93).
This suggests that addressing demographic and comorbid factors may improve weight loss outcomes in T2D patients.
StrongRefutesmedium confidence
Adjustment for covariates differing between trial type and associated with BW reduction nullified the association between T2D status and weight loss (p = 0.93).
Why this rating
Based on a meta-regression of multiple RCTs.
Source
Rethinking diabetes as a modifier of the weight-loss response to incretin-based therapies. A twin trial meta-regression
Marella Marassi et al. · Nutrition Metabolism and Cardiovascular Diseases · 2026
Meta-analysis
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →