Research
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Approximately two-thirds of patients showed stable weight or continued weight loss during the 6 months following their last semaglutide or tirzepatide prescription.
Practitioners can expect that a significant portion of patients may maintain or lose weight after discontinuing GLP-1RA.
StrongSupportsmedium confidence
Approximately two-thirds of patients showed stable weight or continued weight loss during this period.
Why this rating
Based on the large sample size of 4182 patients.
Source
Weight trajectories after last tirzepatide or semaglutide prescription across a federated health network
Karthik Murugadoss et al. · Biology Methods and Protocols · 2026
DOI 10.1093/biomethods/bpag020
cohort · n=4182
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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