Research
Energy balance
Tirzepatide treatment was associated with weight loss comparable to primary study results among participants taking weight-inducing medications.
Practitioners can confidently recommend tirzepatide for weight loss in patients on weight-inducing medications.
StrongSupportsmedium confidence
These findings suggest that people with overweight or obesity who require treatment with WI medications may be able to achieve clinically meaningful weight reduction with tirzepatide.
Why this rating
Based on the post hoc analysis of phase 3 randomized clinical trials.
Source
Weight Changes With Tirzepatide and Concomitant Weight-Inducing Medications
Rodolfo J. Galindo et al. · JAMA Network Open · 2026
DOI 10.1001/jamanetworkopen.2026.3274
rct · n=2539
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide treatment was associated with a mean percentage weight change of -13.3% for 5 mg and -21.3% for 15 mg compared to placebo from randomization to 72 weeks among participants using weight-inducing medications in SURMOUNT-1.Strong
- In SURMOUNT-3, the mean percentage weight change for the maximum tolerated dose of tirzepatide was -26.1% from randomization to 72 weeks among participants using weight-inducing medications.Strong
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