Research
Energy balance
Retatrutide yields a 24.2% reduction in total body weight at 48 weeks with 63% of participants achieving a total body weight loss of ≥20%.
Retatrutide may be an effective option for significant weight loss in patients.
StrongSupportsmedium confidence
Phase 2 clinical data demonstrate that a 12-mg maximal weekly dose yields a 24.2% reduction in total body weight at 48 weeks, with 63% of participants achieving a total body weight loss of ≥20%.
Why this rating
Based on Phase 2 clinical data from a controlled study.
Source
Triple Hormone Receptor Agonism: The Role of Retatrutide in Addressing Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Comprehensive Review
Ashwin A. Pillai et al. · Cardiology in Review · 2026
DOI 10.1097/crd.0000000000001310
review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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