Research
Metabolic adaptation
A high-protein diet, alone or combined with resistance training, induces modest but measurable metabolic shifts without disrupting global metabolic homeostasis.
Older adults can safely increase protein intake without adverse metabolic effects, especially when combined with exercise.
StrongSupportsmedium confidence
These findings suggest that older adults can adapt to elevated protein intake while maintaining metabolic stability, supporting the metabolic safety of a high-protein diet in combination with resistance exercise.
Why this rating
Based on the randomized controlled trial design described in the abstract.
Source
Impact of a high-protein diet with and without strength training over 17 weeks on the plasma metabolome in older adults
Hannah Spahits et al. · Age and Ageing · 2026
DOI 10.1093/ageing/afag010
rct · n=136
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A high-protein diet increased daily protein intake to 1.6 g/kg body weight and resulted in significantly increased concentrations of two metabolites and reduced concentrations of 98 metabolites compared to baseline.Strong
- Most metabolite shifts occurred during the dietary intervention phase, with minimal additional changes after resistance training.Strong
Related findings · Metabolic adaptation
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →