Research
Energy balance
Thiazolidinediones (TZDs) are associated with weight gain, limiting their use as first-line agents for type 2 diabetes.
Practitioners should be cautious in prescribing TZDs due to their association with weight gain.
StrongSupportsmedium confidence
TZDs are associated with weight gain therefore limiting their use as first-line agents.
Why this rating
The claim is based on established observations in diabetes treatment.
Source
Choosing Medications for Weight Loss in Type 2 Diabetes Mellitus
Shubhada Jagasia et al. · 2021
DOI 10.1002/9781119603207.ch15
review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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