Research
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Metformin showed lower risks for cardiovascular disease, acidosis/serious infection, and all-cause mortality compared to insulin and other oral hypoglycaemic agents.
Metformin should be considered as a first-line treatment for T2D due to its favorable risk profile.
StrongSupportsmedium confidence
Metformin showed lower risks for CVD, acidosis/serious infection and all-cause mortality than patients treated with insulin, as well as a lower risk of all-cause mortality than patients treated with other oral hypoglycaemic agents.
Why this rating
Based on the analysis of large cohorts of T2D patients.
Source
Pharmacological Treatment in Patients with Type 2 Diabetes: Benefits and Risks. Epidemiological Studies from the Swedish National Diabetes Register
Nils Ekström · Gothenburg University Publications Electronic Archive (Gothenburg University) · 2014
cohort|cross-sectional|other · n=163121
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