Research
Energy balance
Integrated metrics incorporating phenotypic data show potential for personalizing weight management strategies.
Practitioners should consider using integrated metrics for more effective weight management strategies.
StrongSupportsmedium confidence
suggesting that while GRS based on cross-sectional data may not predict responsiveness to interventions, integrated metrics also incorporating phenotypic data show potential for personalizing weight management strategies.
Why this rating
Based on study design from abstract.
Source
Genetic Risk Scores for Obesity and the Effectiveness of a Diet and Exercise Intervention Program: A Historical Cohort Study
Sho Nakamura et al. · Obesity · 2025
DOI 10.1002/oby.70118
cohort · n=145
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →