Research
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Vitamin E supplementation had a neutral effect on the primary study outcome of major cardiovascular events in people with diabetes.
Practitioners should be aware that vitamin E supplementation does not improve cardiovascular outcomes in high-risk diabetic patients.
StrongRefutesmedium confidence
Vitamin E had a neutral effect on the primary study outcome (relative risk = 1.03, 95% CI 0.88-1.21; P = 0.70).
Why this rating
Based on a large randomized clinical trial.
Source
Effects of Vitamin E on Cardiovascular and Microvascular Outcomes in High-Risk Patients With Diabetes
Eva Lonn et al. · Diabetes Care · 2002
DOI 10.2337/diacare.25.11.1919
rct · n=3654Cited 364×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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