Research
Hormonal
Free cortisol levels remain independent of body composition and leptin levels due to increased cortisol clearance rates.
Cortisol levels may not be a reliable indicator of body fat or leptin levels, suggesting a need for comprehensive assessments.
StrongSupportsmedium confidence
Free cortisol levels remained independent of body composition and leptin levels due to increased cortisol clearance rates.
Why this rating
The study design supports the measurement of cortisol clearance rates.
Source
Association of 24-Hour Cortisol Production Rates, Cortisol-Binding Globulin, and Plasma-Free Cortisol Levels with Body Composition, Leptin Levels, and Aging in Adult Men and Women
Jonathan Q. Purnell et al. · The Journal of Clinical Endocrinology & Metabolism · 2004
DOI 10.1210/jc.2003-030440
cross-sectional · n=54Cited 197×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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