Research
Metabolic adaptation
Changes in glucose and lipid metabolism induced by PI therapy occur without significant changes in weight or fat distribution.
Clinicians should be aware that metabolic changes can occur in HIV patients on PI therapy without changes in weight.
StrongSupportsmedium confidence
We conclude that changes in glucose and lipid metabolism are induced by PI therapy in the absence of significant changes in weight or fat distribution.
Why this rating
The study design involves paired data analysis in a clinical context.
Source
Hyperlipidemia and Insulin Resistance Are Induced by Protease Inhibitors Independent of Changes in Body Composition in Patients With HIV Infection
Kathleen Mulligan et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 2000
cohort · n=41Cited 499×
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