Mixed
Intensive lifestyle interventions (weight loss and physical activity) reduce all-cause mortality in overweight/obese type-2 diabetes patients, despite not significantly reducing cardiovascular events in the Look AHEAD trial.
For people with type-2 diabetes who are overweight, focusing on sustainable weight loss and regular physical activity is crucial for living longer. Even if you don't see immediate improvements in heart disease markers, the long-term data suggests these habits reduce the risk of dying from any cause. Do not rely solely on medication; lifestyle is a primary treatment for longevity.
a more patient-oriented outcome – any cause deaths – showed a promising HR = 0.85 (95% CI 0.69–1.04)... the number of deaths would increase from 376 to 529, with 95% CI 0.71–1.01 and 90% CI 0.73–0.98.
Why this rating
Based on re-analysis of a stopped RCT (Look AHEAD) and observational studies; the primary RCT was stopped for futility regarding CVD, though mortality trended positive.
Source
The importance of lifestyle-based efforts in reducing mortality in overweight and obese individuals with type-2 diabetes
Alberto Donzelli et al. · International Journal of Clinical Practice · 2014
DOI 10.1111/ijcp.12383
Related findings · Mixed
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