Mixed
FDA-approved pharmacologic weight loss medications (lorcaserin, naltrexone/bupropion, phentermine/topiramate, liraglutide, orlistat) produce statistically and clinically significant weight loss and improve cardiovascular/glycemic risk factors when used as adjuncts to lifestyle interventions.
If you have a BMI of 30 or higher (or 27 with health issues like high blood pressure or diabetes), and lifestyle changes alone haven't been enough, FDA-approved weight loss medications are a scientifically supported option. These drugs work alongside diet and exercise to help you lose weight and improve heart health markers. Talk to your doctor about whether you qualify for these treatments, as insurance coverage and prescribing habits vary.
Studies of the five FDA-approved drugs have demonstrated clinically significant positive effects on weight loss with differing effects on both cardiovascular and glycemic markers/risk factors.
Why this rating
Based on a review of 24 randomized clinical trials, including Phase II/III and post-market studies, though it is a review paper rather than a single primary trial.
Source
Pharmacologic Weight Loss: An Underutilized Practice in the Fight Against Obesity
Megumi Howard · Interventions in Obesity & Diabetes · 2021
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