Hormonal
In males with type 2 diabetes, higher baseline endogenous total testosterone and lower estradiol levels significantly enhance the reduction of triglycerides achieved through intensive lifestyle intervention.
If you are a man with type 2 diabetes, your baseline testosterone and estradiol levels may dictate how effectively your diet and exercise efforts lower triglycerides. Men with higher testosterone and lower estradiol tend to see bigger improvements in triglycerides from lifestyle changes. This suggests that knowing your hormone profile could help tailor your lifestyle prescription for better lipid outcomes.
In males, lower baseline E2 and total T significantly augmented ILI-induced triglyceride reductions(p=0.019 and 0.008, respectively) throughout follow up.
Why this rating
Large sample size (n=2260), long follow-up (8 years), and rigorous statistical correction (permutation tests) in a randomized controlled trial ancillary study.
Source
Heterogeneity of effect of Intensive lifestyle intervention on cardiometabolic risk factors by sex hormones in diabetes
Chigolum P. Oyeka et al. · medRxiv · 2025
DOI 10.1101/2025.09.02.25334965
More from this paper
- In females with type 2 diabetes, higher baseline sex hormone-binding globulin (SHBG) significantly enhances the reduction of LDL cholesterol achieved through intensive lifestyle intervention.Good
- Higher baseline total testosterone predicts greater long-term weight loss and waist circumference reduction in both males and females with type 2 diabetes undergoing intensive lifestyle intervention.Good
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