Hormonal
In females with type 2 diabetes, higher baseline sex hormone-binding globulin (SHBG) significantly enhances the reduction of LDL cholesterol achieved through intensive lifestyle intervention.
If you are a postmenopausal woman with type 2 diabetes, your baseline SHBG levels may dictate how effectively your diet and exercise efforts lower LDL cholesterol. Women with higher SHBG tend to see bigger improvements in LDL-C from lifestyle changes. This suggests that knowing your hormone profile could help tailor your lifestyle prescription for better lipid outcomes.
Higher SHBG enhanced LDL-C lowering in females(p=0.018)
Why this rating
Large sample size, long follow-up, and rigorous statistical correction in a randomized controlled trial ancillary study.
Source
Heterogeneity of effect of Intensive lifestyle intervention on cardiometabolic risk factors by sex hormones in diabetes
Chigolum P. Oyeka et al. · medRxiv · 2025
DOI 10.1101/2025.09.02.25334965
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- In males with type 2 diabetes, higher baseline endogenous total testosterone and lower estradiol levels significantly enhance the reduction of triglycerides achieved through intensive lifestyle intervention.Good
- Higher baseline total testosterone predicts greater long-term weight loss and waist circumference reduction in both males and females with type 2 diabetes undergoing intensive lifestyle intervention.Good
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