Mixed
A carbohydrate-reduced telemedicine nutrition intervention significantly reduces the incidence of major adverse cardiovascular events (MACE) and new-onset cardiovascular disease in adults with type 2 diabetes or obesity compared to matched controls.
If you have type 2 diabetes or obesity, a telemedicine program that helps you restrict carbohydrates to under 30 grams per day and maintain nutritional ketosis can significantly lower your risk of heart attacks, strokes, and other cardiovascular events compared to standard care. This approach works by improving overall metabolic health, which appears to protect the heart even if cholesterol levels change.
In this claims-based cohort study, individuals receiving carbohydrate-reduced nutrition therapy had significantly reduced risk of all primary outcomes compared with matched controls: 56% lower 3-point MACE, 48% lower 6-point MACE, 30% lower risk of all new-onset cardiovascular events, and 19% lower new-onset hypertension.
Why this rating
Observational claims-based study with propensity score matching; not a randomized controlled trial.
Source
Real-World Cardiovascular Outcomes with a Carbohydrate-Reduced Telemedicine Intervention
Priya Shanmugam et al. · medRxiv · 2025
DOI 10.1101/2025.10.27.25338916
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