Research
Energy balance
Lifestyle interventions (diet and exercise) remain the most cost-effective and durable strategy for weight loss and diabetes prevention, outperforming microbiome therapies in long-term weight management.
Diet and exercise are the most effective and affordable way to lose weight and prevent diabetes. They outperform probiotics and FMT for weight loss and provide durable benefits.
StrongSupportsVERY_HIGH confidence
Lifestyle interventions were also effective, outperforming probiotics in reducing body weight and improving glucose metabolism... Network comparisons show... lifestyle therapy remains cost-effective for weight reduction
Why this rating
Supported by large, long-term RCTs (Look AHEAD, DPP, PREDIMED).
Source
Harnessing Microbiome Therapy to Treat Metabolic Syndrome
Mustafa Al Jnainati et al. · AACE Endocrinology and Diabetes · 2026
narrative_review
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