Mixed
Adopting a proinflammatory diet (Energy-Adjusted Dietary Inflammatory Index > 0) is associated with significantly increased risks of all-cause mortality, cardiovascular disease, and cancer, whereas maintaining a neutral or anti-inflammatory diet minimizes these risks.
Focus on avoiding proinflammatory foods rather than striving for a perfect anti-inflammatory diet. A neutral diet is likely sufficient to minimize your risk of heart disease and early death. Small, sustainable improvements to reduce inflammatory potential are more effective and maintainable than extreme dietary restrictions.
When E-DII was <0, E-DII was not associated with any of the outcomes. When E-DII was >0, the linear associations were strongest in all-cause mortality (HR 1.09, 95% CI, 1.05-1.13), followed by CVD (HR 1.06, 95% CI, 1.03-1.09), and cancer (HR 1.03, 95%,CI, 1.01-1.05).
Why this rating
Large prospective cohort (n=198,265) with robust sensitivity analyses, but observational design limits causal inference.
Source
Dose-Response Associations of Dietary Inflammatory Potential With Health Outcomes: A Prospective Cohort Study of 198,265 UK Biobank Participants
Frederick K. Ho et al. · Current Problems in Cardiology · 2023
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