Mixed
Twice-daily consumption of a multi-ingredient nutritional supplement (whey protein, creatine, calcium, vitamin D, omega-3s) reduces systemic inflammation (TNF-α, IL-6) in healthy older men, an effect enhanced by subsequent resistance and high-intensity interval training.
Older men looking to reduce chronic, low-grade inflammation should consider a specific multi-ingredient supplement containing whey protein, creatine, calcium, vitamin D, and omega-3 fatty acids, taken twice daily. This nutritional strategy, combined with a mix of resistance and high-intensity interval training, was shown to significantly lower inflammatory markers like TNF-α and IL-6 more effectively than exercise or carbohydrate control alone.
We evaluated whether twice daily consumption of a multi-ingredient nutritional supplement (SUPP) would reduce systemic inflammatory markers following 6wk of supplementation alone (Phase 1), and the subsequent addition of 12wk exercise training (Phase 2) in healthy older men... In the SUPP group, mean plasma TNF-α and IL-6 concentrations each decreased ~1-3% during Phase 1 and a further ~11-12% in response to Phase 2.
Why this rating
Randomized controlled trial with a control group, though the sample size is moderate (n=49) and the supplement is a complex blend, preventing attribution to single ingredients.
Source
A multi-ingredient nutritional supplement enhances exercise training-related reductions in markers of systemic inflammation in healthy older men
Kirsten E. Bell et al. · Applied Physiology Nutrition and Metabolism · 2017
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