Energy balance
Very Low Calorie Diets (VLCD) and significant weight loss (>15 kg) can induce remission of type 2 diabetes in obese patients, primarily by reducing liver fat and restoring insulin sensitivity.
For obese individuals recently diagnosed with type 2 diabetes, a medically supervised Very Low Calorie Diet (approx. 830 kcal/day) for 3-5 months offers the highest chance of reversing the disease. The goal is significant weight loss (ideally >15kg), which reduces liver fat and restores insulin sensitivity, potentially allowing patients to stop medication.
干预组平均减重10 kg. 46%患者完全缓解(HbA1c<6.5%), 74%患者不再需要服药控制血糖...减重>15 kg, 实现86%的缓解率
Why this rating
Based on a specific clinical trial (DiRECT) cited in the text, showing high remission rates, though it is a single study review.
Source
Advances in treatment of obesity-related type 2 diabetes
Dajin Zou · Scientia Sinica Vitae · 2018
DOI 10.1360/n052018-00046
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- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
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- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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