Micronutrients & recovery
Micronutrient deficiencies, specifically low serum zinc and vitamin C, are associated with increased susceptibility to Buruli ulcer, suggesting that nutritional interventions could serve as a prophylactic measure.
In regions with high Buruli ulcer prevalence, improving dietary diversity and ensuring adequate intake of zinc and vitamin C may reduce susceptibility to the disease. This suggests that public health efforts should prioritize nutritional support alongside case detection.
Diet and nutritional status may be a contributing factor to BU pathogenesis. Protein and the micronutrients zinc, selenium, vitamin B12 and vitamin C may be of particular importance. Nutritional interventions may have potential for both prophylaxis and treatment of BU, which may be a cost-effective approach to achieving the NTD Roadmap goals.
Why this rating
Observational study with preprint status; establishes correlation and biological plausibility but not causation or intervention efficacy.
Source
Micronutrient-deficient diets and possible environmental enteric dysfunction in Buruli ulcer endemic communities in Ghana: lower dietary diversity and reduced serum zinc and vitamin C implicate micronutrient status a possible susceptibility factor
Aloysius Dzigbordi Loglo et al. · medRxiv · 2024
DOI 10.1101/2024.07.22.24310811
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