Research
Mixed
High body mass index (BMI) and high fasting plasma glucose are the leading risk factors for years lived with disability and injury in the United States, while high systolic blood pressure and smoking are the leading risk factors for years of life lost.
Focus on managing blood pressure, blood glucose, and body weight, as these are the top drivers of disability and premature death in the US, alongside smoking cessation.
StrongSupportsVERY_HIGH confidence
High body mass index, high fasting plasma glucose, and smoking are the first, second, and third leading years lived with disability and injury risk factors in the United States in both 1990 and 2019... High systolic BP and smoking remained the first and second leading years of life lost risk factors in the United States in both 1990 and 2019.
Why this rating
Based on national statistics and longitudinal data comparisons over decades (1990-2019).
Source
Heart Disease and Stroke Statistics—2021 Update
Salim S. Virani et al. · Circulation · 2021
DOI 10.1161/cir.0000000000000950
narrative_reviewCited 5,710×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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