Hormonal
Hunger states are associated with significantly increased regional cerebral blood flow (neuronal activity) in the hypothalamus, insular cortex, and limbic/paralimbic areas, while satiation states are associated with increased activity in the prefrontal cortex.
This research shows that hunger and fullness are complex brain processes involving multiple regions, not just a single signal. While this doesn't provide a direct diet plan, it highlights that metabolic signals like insulin and free fatty acids play a key role in how the brain perceives hunger and satiation.
Hunger was associated with significantly increased rCBF in the vicinity of the hypothalamus and insular cortex and in additional paralimbic and limbic areas... Satiation was associated with increased rCBF in the vicinity of the ventromedial prefrontal cortex, dorsolateral prefrontal cortex, and inferior parietal lobule.
Why this rating
Small sample size (n=11), exploratory design, and lack of correction for multiple comparisons limit the statistical robustness, though the methodology (PET) is rigorous.
Source
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
P. Antonio Tataranni et al. · Proceedings of the National Academy of Sciences · 1999
DOI 10.1073/pnas.96.8.4569
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