Hormonal
Post-meal increases in plasma insulin and free fatty acids are negatively correlated with neuronal activity in the insular and orbitofrontal cortex (and anterior cingulate for FFA), suggesting these metabolic signals modulate postprandial brain activity.
The brain's response to eating is modulated by metabolic signals like insulin and free fatty acids. Higher levels of these markers after a meal are associated with reduced activity in brain areas linked to hunger processing (insula/orbitofrontal cortex).
Changes in plasma insulin concentrations in response to the meal were negatively correlated with changes in rCBF in the insular and orbitofrontal cortex. Changes in plasma free fatty acid concentrations in response to the meal were negatively correlated with changes in rCBF in the anterior cingulate...
Why this rating
Correlational data from a small sample size; causality is not proven, but the correlation is statistically significant for key regions.
Source
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
P. Antonio Tataranni et al. · Proceedings of the National Academy of Sciences · 1999
DOI 10.1073/pnas.96.8.4569
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