Research

Micronutrients & recovery

Epigenetic modifications, particularly DNA methylation, are altered by weight loss interventions (diet and surgery) and may predict response to treatment.

Your lifestyle choices can change how your genes are expressed (epigenetics). Weight loss through diet or surgery can alter DNA methylation patterns in fat and muscle tissue, potentially improving metabolic health. This suggests that even if you have a history of obesity, lifestyle changes can have biological benefits beyond just weight loss.

ModerateSupportsMEDIUM confidence
Weight loss associated with roux-en-Y gastric bypass surgery... was recently shown to alter the epigenome in adipose tissue, skeletal muscle, and blood.
Molly S. Bray et al. · Obesity · 2015

Why this rating

Based on observational studies and small trials; larger replication needed.

Source

NIH working group report—using genomic information to guide weight management: From universal to precision treatment

Molly S. Bray et al. · Obesity · 2015

narrative_reviewCited 136×
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