Energy balance

Skeletal muscle UCP3 gene expression is negatively correlated with BMI and positively correlated with resting metabolic rate (RMR) in humans, suggesting that reduced UCP3 expression contributes to lower energy expenditure and obesity risk.

Your body's ability to burn energy as heat is partly regulated by genes like UCP3 in your muscles. While you cannot directly 'take' UCP3, understanding that metabolic rate is flexible—and influenced by factors like diet (fasting, fatty acids) and hormones—suggests that metabolic adaptation is possible. Focus on maintaining muscle mass and metabolic health rather than assuming a permanently 'slow' metabolism.