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Hormonal
Orosensory signals (taste and oral contact) activate PRLH neurons in the caudal nucleus of the solitary tract (cNTS) to inhibit feeding on a seconds-timescale, thereby controlling the duration of feeding bursts.
Eating slowly and paying attention to the taste and texture of food engages specific brain circuits (PRLH neurons) that signal satiety within seconds. This neural feedback loop helps you stop eating sooner by reducing the size of each bite or 'bout' of eating, rather than waiting for your stomach to feel full.
StrongSupportsVERY_HIGH confidence
Optogenetic manipulations revealed that PRLH neurons control the duration of seconds-timescale feeding bursts, revealing a mechanism by which orosensory signals feed back to restrain the pace of ingestion.
Why this rating
High-quality experimental evidence using fiber photometry, optogenetics, and single-cell recordings in awake mice.
Source
Sequential appetite suppression by oral and visceral feedback to the brainstem
Truong Ly et al. · Nature · 2023
DOI 10.1038/s41586-023-06758-2
mechanism_onlyCited 84×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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