Research
Hormonal
Visceral feedback from the gut activates GCG neurons in the cNTS to promote long-lasting satiety (tens of minutes) that tracks cumulative food intake.
The physical presence of food in your stomach and intestines activates GCG neurons, which promote a feeling of fullness that lasts for tens of minutes. This visceral feedback tracks how much you have eaten, contributing to long-lasting satiety after a meal.
StrongSupportsVERY_HIGH confidence
By contrast, GCG neurons were activated by mechanical feedback from the gut, tracked the amount of food consumed and promoted satiety that lasted for tens of minutes.
Why this rating
High-quality experimental evidence using fiber photometry and optogenetics in awake mice.
Source
Sequential appetite suppression by oral and visceral feedback to the brainstem
Truong Ly et al. · Nature · 2023
DOI 10.1038/s41586-023-06758-2
mechanism_onlyCited 84×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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