Mixed
In overweight adults with type 2 diabetes (BMI 25-29 kg/m2), long-term intentional weight loss is associated with slightly better mean global cognitive function compared to a control group.
If you are overweight (not obese) and have type 2 diabetes, long-term weight loss might actually support your cognitive health better than staying at your current weight. This is in contrast to obese patients, where weight loss was linked to cognitive decline. Focus on sustainable lifestyle changes that improve your overall health, and discuss cognitive monitoring with your doctor.
Among overweight participants, the mean composite score across repeated assessments was slightly higher among ILI compared with DSE participants: 0.099 (−0.060, 0.259).
Why this rating
RCT with long-term follow-up, but the confidence interval includes 0, making the result marginally significant.
Source
Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial
Mark A. Espeland et al. · The Journals of Gerontology Series A · 2017
DOI 10.1093/gerona/glx165
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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