Mixed
Elevated liver disease activity, measured by MRI-derived iron-corrected T1 (cT1), is independently associated with a higher risk of major cardiovascular events, atrial fibrillation, heart failure, CVD hospitalization, and all-cause mortality.
If you have elevated liver disease activity (measured by MRI cT1), your risk for heart failure, atrial fibrillation, and other cardiovascular events is significantly higher, independent of your liver fat or standard blood tests. This suggests that assessing liver health via advanced imaging may be crucial for cardiovascular risk stratification, even in those without metabolic syndrome.
Liver disease activity (cT1), but not liver fat (PDFF), was associated with a higher risk of any major CVD event [HR(CI) 1.14(1.03-1.26), p=0.008], AF [1.30 (1.12-1.5), p<0.001]; HF [1.30 (1.08 - 1.58), p=0.004]; CVD hospitalisation [1.27(1.18-1.387, p<0.001] and all-cause mortality [1.19(1.02-1.38), p=0.026].
Why this rating
Large-scale longitudinal study (UK Biobank, N=33,616) with multivariable adjustment, but it is an observational association, not a randomized trial.
Source
Liver disease is a significant risk factor for cardiovascular outcomes - a UK Biobank study
Adriana Roca‐Fernández et al. · medRxiv · 2022
DOI 10.1101/2022.12.08.22283242
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