Mixed

In type 2 diabetic patients with normal baseline renal function, baseline obesity (BMI ≥ 25 kg/m²) and longitudinal weight gain exceeding 10% are independently associated with an increased risk of developing decreased renal function (eGFR < 60 mL/min/1.73 m²).

For Type 2 Diabetics with normal kidney function, avoiding obesity (BMI ≥ 25) and preventing significant weight gain (>10%) are key strategies to protect kidney health. Interestingly, simply losing weight may not be enough to lower renal risk if other metabolic factors (blood pressure, lipids, glucose) are not managed, suggesting a holistic approach to metabolic health is required rather than weight loss alone.