Hormonal
High-dose 2'-FL supplementation (5g/day) in older adults significantly increases serum levels of Fibroblast Growth Factor 21 (FGF21) and HDL cholesterol, while depleting octanoylcarnitine.
Older adults taking 5g of 2'-FL daily may see improvements in HDL cholesterol and levels of the hormone FGF21, which regulates lipid metabolism. These changes are associated with the bloom of Bifidobacterium in the gut. The intervention is well-tolerated.
fibroblast growth factor 21 (FGF21) was significantly elevated in the High Dose 2’-FL group vs. the Placebo group (P=0.004... We also found that octanoylcarnitine was depleted in the High Dose 2’-FL group compared to both the Low Dose 2’-FL group (P=0.004... and the Placebo group (P=7.3x10-4... We found that the High Dose 2'-FL group... had significantly increased high-density lipoprotein cholesterol at End of intervention (Week 6) compared to Baseline
Why this rating
Statistically significant findings in a randomized controlled trial, though the primary endpoint (cytokine score) was not met.
Source
A human milk oligosaccharide alters the microbiome, circulating hormones, cytokines and metabolites in a randomized controlled trial of older individuals
Matthew M. Carter et al. · medRxiv · 2023
DOI 10.1101/2023.08.18.23294085
More from this paper
- 2'-FL supplementation does NOT significantly alter the Cytokine Response Score (CRS), a marker of immune aging, in older adults, despite increasing Bifidobacterium.Strong
- Consumption of 5g/day of the human milk oligosaccharide 2'-fucosyllactose (2'-FL) for 6 weeks significantly increases the relative abundance of Bifidobacterium in the gut microbiota of healthy older adults.Good
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