Mixed
2'-FL supplementation does NOT significantly alter the Cytokine Response Score (CRS), a marker of immune aging, in older adults, despite increasing Bifidobacterium.
Taking 2'-FL (1g or 5g daily) for 6 weeks did not improve the Cytokine Response Score, a marker of immune aging, in older adults. However, it did increase Bifidobacterium and HDL cholesterol. Users should not expect this to reverse immune aging markers based on this study.
We did not observe significant changes in CRS between treatment groups or from baseline to end of intervention within any of the three groups
Why this rating
This is the primary endpoint of a randomized controlled trial, directly addressing the study's main hypothesis.
Source
A human milk oligosaccharide alters the microbiome, circulating hormones, cytokines and metabolites in a randomized controlled trial of older individuals
Matthew M. Carter et al. · medRxiv · 2023
DOI 10.1101/2023.08.18.23294085
More from this paper
- Consumption of 5g/day of the human milk oligosaccharide 2'-fucosyllactose (2'-FL) for 6 weeks significantly increases the relative abundance of Bifidobacterium in the gut microbiota of healthy older adults.Good
- High-dose 2'-FL supplementation (5g/day) in older adults significantly increases serum levels of Fibroblast Growth Factor 21 (FGF21) and HDL cholesterol, while depleting octanoylcarnitine.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →