Research
Mixed
2'-FL supplementation does NOT significantly alter the Cytokine Response Score (CRS), a marker of immune aging, in older adults, despite increasing Bifidobacterium.
Taking 2'-FL (1g or 5g daily) for 6 weeks did not improve the Cytokine Response Score, a marker of immune aging, in older adults. However, it did increase Bifidobacterium and HDL cholesterol. Users should not expect this to reverse immune aging markers based on this study.
StrongRefutesHIGH confidence
We did not observe significant changes in CRS between treatment groups or from baseline to end of intervention within any of the three groups
Why this rating
This is the primary endpoint of a randomized controlled trial, directly addressing the study's main hypothesis.
Source
A human milk oligosaccharide alters the microbiome, circulating hormones, cytokines and metabolites in a randomized controlled trial of older individuals
Matthew M. Carter et al. · medRxiv · 2023
preprint · n=89Cited 4×
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