Macro partitioning
In carriers of the BDNF rs10835211 GG genotype, high carbohydrate intake (>48% of energy) is associated with lower fat-free mass and skeletal muscle mass compared to lower intake, whereas high fiber intake (>18g/day) is associated with higher fat-free mass but also higher total cholesterol and LDL-C.
If you carry the BDNF rs10835211 GG genotype, your body composition response to macronutrients differs from the general population. High carbohydrate intake (>48% of calories) may be associated with lower muscle mass in this group. However, ensuring adequate fiber intake (>18g/day) may support higher fat-free mass, though it was also linked to higher cholesterol in this specific study. Focus on fiber-rich carbohydrate sources and monitor lipid profiles.
We noted that participants carrying the GG genotype had lower skeletal muscle mass and fat free mass (FFM) when carbohydrate intake was > 48%, whereas they presented higher fat‑free mass (FFM), and surprisingly higher total cholesterol and LDL‑C concentrations when daily fiber intake was > 18 g.
Why this rating
Cross-sectional observational study with a moderate sample size (N=484) and stratification into subgroups reduces statistical power and prevents causal inference.
Source
Obesity-related parameters in carriers of some BDNF genetic variants may depend on daily dietary macronutrients intake
Urszula Miksza et al. · Scientific Reports · 2023
DOI 10.1038/s41598-023-33842-4
More from this paper
- In BDNF rs10835211 GG genotype carriers, high protein intake (>18% of energy) is associated with higher waist circumference, BMI, body fat, and insulin resistance (HOMA-IR), while high fat intake (>30% of energy) is associated with higher visceral adipose tissue (VAT) and HDL-C.Moderate
- In BDNF rs10835211 GG genotype carriers, higher daily energy intake (>1800 kcal) is associated with lower fasting insulin, lower HbA1c, and lower HOMA-IR compared to lower energy intake, despite similar or higher body weight.Moderate
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