Research
Adherence
Intensive lifestyle interventions (diet and exercise) aiming for weight loss and increased physical activity do not significantly reduce cardiovascular morbidity or mortality in patients with type 2 diabetes compared to standard care, despite improving surrogate markers.
While diet and exercise are crucial for feeling better and managing blood sugar, do not rely on them alone to prevent heart attacks or death in type 2 diabetes. You likely need medication to manage blood pressure and lipids alongside lifestyle changes to protect your heart.
GoodRefutesHIGH confidence
Trotz des Effektes auf einige Surrogatparameter und zumindest anfangs verbesserter physischer „Fitness“ ergab sich enttäuschenderweise keine signifikante Verbesserung der kardiovaskulären Endpunkte.
Why this rating
Based on the Look AHEAD study, a large, multicenter, long-term randomized controlled trial.
Source
Die Behandlung des Diabetes mellitus: Mythen und Evidenz
Burkhard Göke · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · 2020
DOI 10.1007/s00103-020-03124-9
narrative_reviewCited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Aggressive blood glucose lowering (targeting HbA1c < 6.5%) in type 2 diabetes does not necessarily reduce cardiovascular risk and may increase overall mortality due to side effects like hypoglycemia and weight gain.Strong
- Multifactorial intervention targeting blood glucose, blood pressure, and lipids reduces cardiovascular mortality in type 2 diabetes more effectively than standard care focused only on glucose.Strong
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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