Research
Hormonal
Acarbose, an alpha-glucosidase inhibitor, reduces the risk of cardiovascular disease and postprandial hypotension by slowing carbohydrate digestion and absorption.
For high-risk patients with impaired glucose tolerance, Acarbose (50-100mg at breakfast) can significantly reduce cardiovascular risk and postprandial hypotension by slowing carbohydrate absorption.
GoodSupportsHIGH confidence
Acarbose has been also shown to reduce the development of diabetes and also CVD in the STOP NIDDM (Study to Prevent Non-Insulin-Dependent Diabetes Mellitus) trial by 49%
Why this rating
Based on the STOP NIDDM trial and meta-analyses cited.
Source
The Glycemic Index, Postprandial Hypotension and Cardiovascular Disease
Ayan Agarwal et al. · International Journal on Heart and Vascular system · 2021
DOI 10.51626/ijhvs.2021.01.00003
narrative_reviewCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High glycemic index (GI) diets increase cardiovascular disease (CVD) risk and all-cause mortality, potentially mediated by postprandial hypotension (PPH) and oxidative stress.Good
- Postprandial hypotension (PPH), defined as a systolic BP drop of ≥20 mmHg within 2 hours of eating, is an independent predictor of all-cause mortality, syncope, angina, and stroke, particularly in the elderly.Good
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