Mixed
Leucine-rich high protein supplementation (50.6 g protein and 6 g leucine daily) does not significantly improve body composition or muscle function in older adults with sarcopenia over a 12-week period, despite upregulating specific gene expression related to ATP production and DNA repair.
For older adults with sarcopenia, taking leucine-rich protein supplements alone for 12 weeks will not significantly increase muscle mass or improve physical function. While it may positively influence gene expression related to energy production, it is not a standalone solution for reversing sarcopenia. To see functional benefits, supplementation should likely be combined with resistance exercise.
Leucine-rich high protein supplementation did not produce significant changes in body composition or muscle function in older adults with sarcopenia. However, it showed potential in improving gene expression.
Why this rating
Randomized controlled trial with double-blinding, though limited by a small sample size (n=47) and high dropout rate.
Source
Efficacy of leucine-rich high protein supplementation on body composition and muscle function among older adults with sarcopenia: a randomized controlled trial
Swin Xin Chung et al. · European Journal of Nutrition · 2026
DOI 10.1007/s00394-025-03845-0
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