Research
Hormonal
Metabolic bariatric surgery (MBS) is the most effective intervention for achieving long-term and sustained weight loss and can reverse certain metabolic defects like insulin resistance by altering gut hormone secretion.
For severe obesity, lifestyle changes alone are often insufficient. Metabolic bariatric surgery (like gastric bypass) is currently the most effective treatment for long-term weight loss and can reverse metabolic issues like diabetes by changing gut hormones.
StrongSupportsHIGH confidence
At present, MBS, including sleeve gastrectomy (SG), one-anastomosis gastric bypass (OAGB), and Roux-en-Y gastric bypass (RYGB), remains the most effective therapeutic option for obesity, offering long-lasting weight loss.
Why this rating
Supported by multiple statements calling it the 'most effective' and 'revolutionary prospects'.
Source
Obesity and Its Comorbidities: Current Treatment Options, Emerging Biological Mechanisms, Future Perspectives and Challenges
Lihua Wang et al. · Diabetes Metabolic Syndrome and Obesity · 2025
DOI 10.2147/dmso.s540103
narrative_reviewCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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