Research
Hormonal
Obesity increases the risk of various cancers, including breast, endometrial, ovarian, kidney, thyroid, and gastrointestinal cancers, through mechanisms involving chronic inflammation, adipokine secretion, and epigenetic dysregulation.
Obesity increases your risk of several types of cancer, including breast, endometrial, and gastrointestinal cancers. This risk is driven by chronic inflammation and hormones secreted by fat tissue.
GoodSupportsHIGH confidence
Obesity has been linked to an increased risk of cancer development, with 11.9% of cancer cases in men and 13.1% in women attributed to obesity globally.
Why this rating
Supported by systematic reviews, meta-analyses, and mechanistic studies.
Source
Obesity and Its Comorbidities: Current Treatment Options, Emerging Biological Mechanisms, Future Perspectives and Challenges
Lihua Wang et al. · Diabetes Metabolic Syndrome and Obesity · 2025
DOI 10.2147/dmso.s540103
narrative_reviewCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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