Hormonal
Obesity causes chronic kidney disease directly through adaptive glomerular changes (glomerulopathy associated with obesity) and indirectly by increasing the risk of hypertension and type 2 diabetes.
Maintaining a healthy weight is critical for kidney health. Obesity directly stresses the kidneys through increased blood flow and filtration pressure, leading to scarring (glomerulosclerosis). Weight loss, along with managing blood pressure and blood sugar, is the most effective way to prevent kidney damage.
Obesity can cause chronic kidney disease both indirectly, as a major risk factor for diabetes and hypertension, and directly, through adaptive glomerular changes that evolve into a specific form of glomerulopathy.
Why this rating
The paper is a review citing multiple cohort studies and animal models, establishing strong mechanistic and epidemiological links.
Source
Obesidade e doença renal: aspectos fisiopatológicos
João Eduardo Cascelli Schelb Scalla Pereira et al. · HU Revista · 2019
DOI 10.34019/1982-8047.2018.v44.13982
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